5 DNA Adducts and Their Consequences
نویسندگان
چکیده
1. the majority of carcinogens are also mutagens; 2. the mutagenic and carcinogenic properties of many carcinogens depend upon their conversion to electrophilic derivatives that react with nucleophilic sites within DNA; 3. the extent of DNA adduct formation can often be correlated with the magnitude of mutagenic and carcinogenic responses; and 4. the activation of certain proto-oncogenes can be accomplished through the interaction of carcinogens with DNA.
منابع مشابه
Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts.
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تاریخ انتشار 2005